Prognostic study of 18F-FDG PET/CT combined with clinical characteristics in treated patients with esophageal squamous cell carcinoma
10.13406/j.cnki.cyxb.003778
- VernacularTitle:18F-FDG PET/CT联合临床特征对食管鳞癌患者治疗后的预后研究
- Author:
Di ZHANG
1
;
Hua PANG
;
Xinyi REN
;
Gang CHENG
Author Information
1. 重庆医科大学附属第一医院核医学科,重庆 400016
- Keywords:
esophageal squamous cell carcinoma;
prognosis;
fluorodeoxyglucose;
positron emission tomography
- From:
Journal of Chongqing Medical University
2025;50(5):694-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the prognostic value of 18F-fluorodeoxyglucose(FDG)positron emission tomography(PET)/com-puted tomography(CT)(18F-FDG PET/CT)metabolic parameters combined with clinical characteristics in treated patients with esophageal squamous cell carcinoma(ESCC).Methods:The clinical data of 75 patients(65 males and 10 females,age of 63.41±7.75 years)with pathologically confirmed ESCC in * Hospital from January 2015 to November 2021 were retrospectively analyzed.All pa-tients underwent 18F-FDG PET/CT examination after treatment.The relevant parameters of 18F-FDG PET/CT were determined:whole body SUVmax(SUVmaxwb);SUVmean and metabolic tumor volume(MTV)were measured with 40％SUVmax as the critical value,and whole body MTV(MTVwb)and whole body total lesion glycolysis(TLGwb)were calculated.Kaplan-Meier survival curves and Cox proportional hazards model were used to evaluate the relationship between PET parameters and overall survival(OS).Results:Fifty-two(69.3％)patients died.PET-positive patients exhibited a 6.029-fold increased risk of death compared with PET-negative patients(P<0.001),with the median survival time of 22.3 months and 43.2 months,respectively.PET-positive patients were catego-rized based on median parameters of PET:SUVmaxwb=11.09,MTVwb=27.07 cm3,and TLGwb=162.34 g.Kaplan-Meier survival curves and log-rank tests revealed the correlations of pathological classification,M stage,post-PET anti-tumor treatment,MTVwb,and TLGwb with OS.M stage emerged as an independent predictor for OS(hazard ratio=5.698,95％CI=1.791-18.123,P=0.003).Patients positive for both PET imaging and serology had a 6.112-fold higher death risk compared with those negative for PET imaging(P<0.001).Conclusion:18F-FDG PET/CT volume metabolism parameters are significant prognostic predictors for treated patients with ESCC,and patients positive for PET imaging and tumor markers are associated with a poor prognosis.
