Influence of cytoplasmic strings during blastocyst expansion on embryonic development and pregnancy outcome
10.13406/j.cnki.cyxb.003827
- VernacularTitle:囊胚扩张期胞质丝存在对胚胎发育和妊娠结局的影响
- Author:
Jiahong ZHU
1
;
Jiayi ZOU
;
Jiang WANG
;
Shun XIONG
;
Guoning HUANG
;
Wei HAN
;
Yang GAO
Author Information
1. 重庆市妇幼保健院人类胚胎工程重庆市重点实验室,重庆 400013
- Keywords:
blastocyst;
cytoplasmic strings;
morphological quality;
euploidy;
pregnancy outcome
- From:
Journal of Chongqing Medical University
2025;50(5):688-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of inner cell mass and trophectoderm cytoplasmic strings during blastocyst expan-sion on embryonic development and pregnancy outcome.Methods:A retrospective cohort analysis was performed for the clinical data of patients who received pre-implantation genetic testing for aneuploidy(PGT-A)and underwent single blastocyst transplantation in our hospital from June 2019 to December 2021.A total of 530 patients were enrolled,and genetic testing was performed for 2132 blasto-cysts.According to the presence or absence of cytoplasmic strings during blastocyst expansion,the blastocysts were divided into cyto-plasmic strings(+)group with 534 blastocysts and cytoplasmic strings(-)group with 1598 blastocysts,and quality and PGT-A results were compared between the two groups.After the transfer of euploid blastocysts,pregnancy outcome was compared between the 115 blastocysts with cytoplasmic strings and the 415 blastocysts without cytoplasmic strings.Results:The rates of cytoplasmic strings(+)in the high-,average-,and low-quality blastocyst groups were 30.19%,24.62%,and 12.63%,respectively.The correlation analysis showed a correlation coefficient of-0.115(P<0.001)between embryo quality and the rate of cytoplasmic strings(+).There was no sig-nificant difference in euploidy rate between the two groups(45.3%vs.44.6%).There were no significant differences between the euploid blastocysts with cytoplasmic strings and those without cytoplasmic strings in implantation rate(72.17%vs.66.02%,P=0.213),miscarriage rate(14.46%vs.12.77%,P=0.691),and live birth rate(61.74%vs.57.59%,P=0.424).Conclusion:The presence of cyto-plasmic strings is associated with the morphological quality of blas-tocysts,while it has no impact on embryo ploidy or clinical outcome after euploid embryo transfer.Further research is needed to confirm the impact of cytoplasmic strings on embryonic development.
