Research advances in the role and mechanism of tryptophan metabolism in tumor development and progression
10.13406/j.cnki.cyxb.003801
- VernacularTitle:色氨酸代谢在肿瘤发生发展中的研究进展
- Author:
Leng HAN
1
;
Xinting ZHU
;
Jiayu ZHANG
;
Cheng GUO
;
Quanjun YANG
Author Information
1. 上海交通大学医学院附属第六人民医院药剂科,上海 200233
- Keywords:
tryptophan metabolism;
tumor development;
tumor therapy;
indoleamine 2,3-dioxygenase
- From:
Journal of Chongqing Medical University
2025;50(5):585-588
- CountryChina
- Language:Chinese
-
Abstract:
Amino acids are essential nutrients for the survival of all cells in the body,and their metabolic processes are closely associ-ated with tumor development and progression.The metabolic changes of the essential amino acid tryptophan have a significance impact on tumor microenvironment.Tryptophan is mainly metabolized to kynurenine(KYN)by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase,and the accumulation of KYN and the deficiency of tryptophan cause alterations in the immune status in tumor micro-environment,which in turn affects tumor development and progression.Based on the current studies on tryptophan,this article system-atically discusses the influence of abnormal tryptophan metabolism on tumors and the interventions targeting this pathway,in order to provide a reference for subsequent tumor therapy.
