Role of lidocaine in assisting the treatment of different types of tumor:basic and clinical evidence
10.13406/j.cnki.cyxb.003640
- VernacularTitle:利多卡因对不同肿瘤治疗的辅助作用:基础与临床证据
- Author:
Jiahui ZHAO
1
;
Yongzheng HAN
;
Min LI
;
Chang LIU
Author Information
1. 北京大学第三医院麻醉科,北京 100191
- Keywords:
lidocaine;
tumor;
proliferation;
invasion and metastasis;
chemotherapy;
perioperative period
- From:
Journal of Chongqing Medical University
2025;50(5):579-584
- CountryChina
- Language:Chinese
-
Abstract:
Lidocaine,as an amide local anesthetic,is widely used in cancer patients in the perioperative period.This article summa-rizes the effect of lidocaine on cell proliferation,invasion,and metastasis of common tumors in clinical practice based on both basic and clinical studies,including breast cancer,gastric cancer,colon cancer,and lung cancer,and it also reviews the clinical application of li-docaine in the perioperative treatment of patients with these four types of cancer.It is necessary to explore the mechanism of action of li-docaine in various types of cancer,develop individualized administration regimens based on the treatment characteristics of different tu-mors,and optimize perioperative treatment strategies for cancer patients through novel formulations,which may provide a theoretical ba-sis for lidocaine in assisting tumor therapy in the perioperative period.
