Research advances in sentinel factors for cancer-related cognitive impairment and related assessment tools in children with leukemia

VernacularTitle:白血病患儿癌症相关认知障碍前哨因子及其评估工具研究进展
Author: Yan ZENG ¹ ; Lin MO ; Zefang CHEN ; Tao LIU
Author Information

1. 重庆医科大学护理学院/附属儿童医院护理部,重庆 400014
Keywords: leukemia; cognitive impairment; cancer; children
From: Journal of Chongqing Medical University 2025;50(4):482-487
CountryChina
Language:Chinese
Abstract: Cancer-related cognitive impairment is a common and serious complication in children with leukemia,which affects the quality of long-term survival and has adverse impact on their schooling,life,and socialization.Through a literature review,this article summarizes the sentinel factors for cancer-related cognitive impairment,including insomnia,anxiety,depression,high-dose methotrex-ate exposure,decreased lysophosphatidylcholine levels and elevated sphingomyelin concentrations in cerebrospinal fluid,MTHFR1298 genotype,and increases in inflammatory factors(TNF-α,IL-6,and IL-8).The existing assessment tools for sentinel factors lack sensi-tivity and specificity,and subsequent large-sample multicenter studies should be conducted to validate the accuracy of the above indi-cators in predicting cancer-related cognitive impairment in children with leukemia,so as to achieve early intervention and improve the quality of long-term survival.