Research advances in clinical subtypes of Alzheimer's disease based on clinical manifestations and pathological features
10.13406/j.cnki.cyxb.003773
- VernacularTitle:基于临床表现和病理学特征的阿尔茨海默病临床亚型研究进展
- Author:
Juan ZHOU
1
;
Deyang ZENG
;
Xiaochang LIU
;
Yan ZENG
;
Zhaolan HUANG
;
Xue YANG
;
Xing WANG
;
Wei TAN
Author Information
1. 武汉科技大学公共卫生学院,武汉 430065
- Keywords:
Alzheimer's disease;
heterogeneity;
clinical subtype;
molecular pathology;
molecular imaging
- From:
Journal of Chongqing Medical University
2025;50(4):476-481
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a neurodegenerative disease with highly heterogeneous pathological and clinical manifesta-tions,and it is the most common cause of dementia.This heterogeneity poses challenges for diagnosis,treatment,and evaluating novel pharmacological efficacy.This review summarizes the latest progress in the major clinical subtypes of AD based on clinical manifesta-tions,genetic,and pathological features.Early-onset and late-onset AD clinical subtypes may share the same symptoms but differ in etiology,age of onset,mode of presentation,disease progression,and associated comorbidities.Typical and atypical AD differ signifi-cantly in clinical manifestations,pathological features,and diagnostic criteria.Research on AD subtypes based on imaging and omics data has also made considerable progress.This review also outlines the molecular pathological heterogeneity of AD.A deep understand-ing of these heterogeneities is crucial for diagnosis,the formulation of pharmacological treatment strategies,and clinical management.
