Correlation of neonatal birth weight with urinary microproteins and creatinine in adulthood
10.13406/j.cnki.cyxb.003806
- VernacularTitle:新生儿出生体质量与成年后尿微量蛋白及尿肌酐相关性的临床研究
- Author:
Zijun DING
1
;
Xiaolin WANG
Author Information
1. 山西医科大学儿科系,山西 030619
- Keywords:
neonatal birth weight;
urinary creatinine;
urinary mi-croproteins;
Mendelian randomization;
Pearson correlation analysis
- From:
Journal of Chongqing Medical University
2025;50(4):449-456
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation and causal relationship between neonatal birth weight and urinary microproteins and creatinine in adulthood.Methods:Genome-wide association studies were conducted to extract genetic loci with significant influ-ence from dataset as instrumental variables,and they were analyzed by inverse variance weighted(IVW),weighted median,MR Egger,and MR-PRESSO methods to investigate the causal relationship between neonatal birth weight and urinary microproteins and creati-nine in adulthood.A retrospective analysis was performed for 113 neonates who were admitted to Department of Neonatology,Shanxi Children's Hospital,from January 2005 to January 2007,and related data were collected during the neonatal and adult stages.A Pear-son correlation analysis was used to determine the correlation between neonatal birth weight and urinary microproteins and creatinine in adulthood.Results:The MR-IVW test showed that neonatal birth weight had a statistically significant correlation with urinary micro-proteins(P=0.037)and urinary creatinine(P=0.015)in adulthood.The retrospective study showed that there were no significant differ-ences between the two groups in all variables except body weight(P>0.05).In addition,the Pearson correlation analysis showed that neonatal birth weight was negatively correlated with urinary microproteins(r=-0.78,P=0.015)and was positively correlated with uri-nary creatinine(r=0.78,P=0.018).Conclusion:Neonatal birth weight is negatively correlated with urinary microproteins and is positively correlated with urinary creatinine in adulthood.
