Research advances in the pathogenesis and pathophysiological manifestations of interstitial cystitis caused by urothelial cell pyroptosis
10.13406/j.cnki.cyxb.003820
- VernacularTitle:膀胱尿路上皮细胞焦亡在间质性膀胱炎发病机制及其病理生理表现中的研究进展
- Author:
Lei PANG
1
;
Weibing SHUANG
Author Information
1. 山西省人民医院泌尿外科,山西 030012
- Keywords:
interstitial cystitis;
pyroptosis;
DNA methylation;
mitochondrial oxidative damage
- From:
Journal of Chongqing Medical University
2025;50(4):426-431
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a proinflammatory form of regulated cell death that can lead to the activation of inactive cytokines and the cleavage of gasdermin D in cells.The main pathological outcome of inflammatory bladder disease is the loss of bladder compliance,and cell pyroptosis plays an important role in this process.Some studies have shown that cell pyroptosis is regulated by various mechanisms such as DNA methylation and mitochondrial DNA oxidative damage,which intervene in the biological behavior of bladder urothelial cells in interstitial cystitis and induce impairment of bladder compliance.Therefore,this article reviews the regulatory mechanisms of cell pyroptosis in interstitial cystitis and the potential role of pyroptosis in inflammatory bladder diseases,in order to explore potential diagnostic biomarkers for interstitial cystitis and facilitate the prevention and treatment of interstitial cystitis.
