Role of chloride ions in the prognosis of patients with decompensated cirrhosis
10.13406/j.cnki.cyxb.003746
- VernacularTitle:氯离子在肝硬化失代偿期患者预后中的角色
- Author:
Tian MENG
1
;
Ouyang JING
;
Chang HONG
;
Yang JIN
;
Liu MIN
;
Yuping WANG
;
Zhaofeng CHEN
Author Information
1. 兰州大学第一临床医学院,兰州 730000
- Keywords:
cirrhosis;
prognosis;
serum sodium ion;
serum chloride ion
- From:
Journal of Chongqing Medical University
2025;50(3):367-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic value of serum chloride ion concentration in critically ill or clinically stable pa-tients with decompensated cirrhosis.Methods:A retrospective study was conducted among the patients with decompensated cirrhosis who attended the intensive care unit(ICU)and Department of Gastroenterology,The First Hospital of Lanzhou University,from Janu-ary 2017 to January 2022,and the patients were divided into ICU cohort and Gastroenterology cohort.The outcome event for the ICU cohort was in-hospital death.A logistic regression analysis was used to investigate the association between serum chloride levels and ICU mortality rate;the receiver operating characteristic(ROC)curve was plotted and the area under the ROC curve(AUC)was calcu-lated to assess the value of blood chloride level in predicting ICU mortality rate.The patients in the Gastroenterology cohort were fol-lowed up with the outcome event of all-cause mortality rate,and the Cox regression analysis and the Kaplan-Meier analysis were used to investigate the value of blood chloride level in predicting mortality rate.Results:In the ICU cohort,serum chloride ion was signifi-cantly associated with in-hospital mortality in the ICU(odds ratio=0.934,95%CI=0.871-0.993,P=0.035),and blood chlorine had an AUC of 0.687 in predicting in-hospital mortality in the ICU.In the Gastroenterology cohort,serum chloride ion concentration was sig-nificantly associated with mortality rate in the subgroup with a Child-Pugh score of<10(hazard ratio=0.906,95%CI=0.822-0.997,P=0.043),and hypochloremia was associated with a lower survival rate.Conclusion:Hypochloremia is associated with the increase in mortality rate in patients with decompensated cirrhosis.
