Progress of GARP protein from tumor immune evasion to immunotherapy
10.3760/cma.j.cn115356-20241225-00190
- VernacularTitle:GARP蛋白：从肿瘤免疫逃逸到免疫治疗的研究进展
- Author:
Hexian GONG
1
;
Hui SONG
;
Yanan MIN
Author Information
1. 济宁医学院临床医学院，济宁 272007
- Keywords:
GARP protein;
Regulatory T cell;
Tumor escape;
Transforming growth factor-β;
Immunotherapy
- From:
Journal of Leukemia & Lymphoma
2025;34(9):569-573
- CountryChina
- Language:Chinese
-
Abstract:
GARP is a key molecule on regulatory T cells (Treg cells) that stabilizes and activates the immune regulation of potential active latent transforming growth factor-β (LTGF-β). Recent studies have revealed that GARP contributes to tumor immune evasion by promoting tumor immunosuppression and inhibiting effector T cell function, and GARP is closely associated with various immune-related diseases. Therapeutic strategies targeting the GARP-TGF-β axis, including monoclonal antibodies and genetic engineering techniques, show a promising potential in enhancing antitumor immune responses and regulating excessive inflammation. This review summarizes GARP's role and explores its application in tumor immunotherapy and inflammatory diseases management, providing a reference for future therapies for GARP.
