Current status and influencing factors analysis of medication literacy in patients undergoing allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.cn115356-20250305-00031
- VernacularTitle:异基因造血干细胞移植患者药物素养现状及影响因素分析
- Author:
Lijun JIANG
1
;
Meihua CHEN
Author Information
1. 福建医科大学附属协和医院血液科护理病房，福州 350000
- Keywords:
Hematopoietic stem cell transplantation;
Medication literacy;
Continuity of care;
Medication education
- From:
Journal of Leukemia & Lymphoma
2025;34(9):542-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the current status of medication literacy in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its influencing factors.Methods:A cross-sectional study was conducted. According to a stratified random sampling strategy, 105 patients undergoing allo-HSCT were recruited from Fujian Medical University Union Hospital between January and August 2024. General information questionnaire and medication literacy scale were used to collect the demographic characteristics and clinical information of patients. The influencing factors of medication literacy score were analyzed. Univariate analysis was performed by using the Mann-Whitney U test and the Kruskal-Wallis rank sum test; medication literacy scores were compared among subgroups and multivariate analysis was performed by using multiple linear regression model. Results:A total of 105 questionnaires were distributed and returned, yielding 100 valid questionnaires (95.2% valid response rate). Among 100 patients, 54 were male and 46 were female. The medication literacy median score [ M ( Q1, Q3)] was 5 (3, 7) points, indicating a moderate level. Univariate analysis revealed that the medication literacy total score of patients aged <55 years was higher than that of those aged ≥ 55 years ( P = 0.05). The medication literacy score of patients with college education and above was higher than that of those with secondary school or high school, junior high school and below education. Patients with a monthly per capita household income of 4 001-6 000 yuan and >6000 yuan had a higher medication literacy total score compared with those with income of ≤ 2 000 yuan and 2 001-4 000 yuan, and the differences were statistically significant (all P < 0.05). Multivariate analysis showed that aged (< 55 years vs. ≥ 55 years, B = 1.160, 95% CI: 0.488-1.832, P = 0.001), education level (secondary school or high school vs. junior high school and below education, B = 1.888, 95% CI: 1.284-2.492, P < 0.001; college education and above vs. junior high school and below education, B = 3.020, 95% CI: 2.482-3.558, P < 0.001), a monthly per capita household income (4 001-6 000 yuan vs. ≤ 2 000 yuan, B = 0.672, 95% CI: 0.058-1.287, P = 0.032; >6000 yuan vs. ≤2 000 yuan, B = 0.692, 95% CI: 0.020-1.363, P = 0.044) were independent influencing factors of medication literacy total score of patients undergoing allo-HSCT. Conclusions:The medication literacy of patients undergoing allo-HSCT is at middle level and it needs improvement. It is necessary to formulate stratified intervention strategies targeting older patients, those with lower education level and lower income, to optimize to medication information delivery and to strengthen the connection of post-discharge care.
