Progress of immune cells in preservation of GVL effect after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.cn115356-20240716-00107
- VernacularTitle:免疫细胞在异基因造血干细胞移植后保留GVL效应中的研究进展
- Author:
Yuan LIU
1
;
Zengzheng LI
;
Tonghua YANG
Author Information
1. 昆明理工大学医学院，昆明 650500
- Keywords:
Hematopoietic stem cell transplantation;
Graft vs host disease;
Graft vs leukemia;
Treatment outcome
- From:
Journal of Leukemia & Lymphoma
2025;34(8):509-512
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment strategy for hematologic malignancies such as leukemia. Allo-HSCT rebuilds the hematologic and immune systems and exerts graft-versus-leukemia (GVL) effect, but at the same time it poses a risk of causing acute graft-versus-host disease (aGVHD). However, the challenge of preserving the GVL effect while preventing aGVHD remains unsolved. In current clinical treatment, immunosuppressants are mainly used to treat severe aGVHD, but the treatment effect is not satisfactory, and immunosuppressants can weaken or eliminate the GVL effect. aGVHD is mainly due to host response to graft and host challenge by donor T cells and cytokines in the early post-allo-HSCT period. T cell-mediated alloreactivity is the key to the GVL effect. In patients who have undergone allo-HSCT, the GVL effect should be more effective in the presence of aGVHD. This article reviews the impact and application of immune cells such as T cells on the preservation of GVL effect after allo-HSCT, aiming to provide new ideas and directions for the preservation of GVL effect.
