Rare relapsed TTMV::RARA fusion gene-positive pediatric acute promyelocytic leukemia: report of 1 case and review of literature
10.3760/cma.j.cn115356-20250217-00019
- VernacularTitle:罕见TTMV：：RARA融合基因阳性儿童急性早幼粒细胞白血病复发1例并文献复习
- Author:
Ting ZHAO
1
;
Luyue DING
;
Jianwen ZHOU
;
Pengkai FAN
;
Mingfa GUO
;
Chunxiang LI
;
Yutai SU
;
Yanna MAO
;
Ping MA
Author Information
1. 郑州大学附属儿童医院 河南省儿童医院血液肿瘤科，郑州 450018
- Keywords:
Leukemia, promyelocytes, acute;
Torque teno mini virus;
TTMV::RARA fusion gene;
Child
- From:
Journal of Leukemia & Lymphoma
2025;34(8):494-497
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the understanding of pediatric acute promyelocytic leukemia with TTMV::RARA fusion gene positive caused by torque teno mini virus (TTMV).Methods:A retrospective analysis was conducted on the clinical data of a patient with relapsed TTMV::RARA fusion gene-positive acute promyelocytic leukemia who was admitted to Children's Hospital Affiliated to Zhengzhou University in July 2024, and literature review was conducted.Results:The patient was a girl with the age of 5 years and 7 months. She presented with joint pain and fever. Combined with bone marrow cell morphology and whole transcriptome sequencing, she was diagnosed with TTMV::RARA fusion gene-positive acute promyelocytic leukemia. After induction therapy with regimens such as retinoic acid +daunorubicin+cytarabine and retinoic acid+venetoclax+homoharringtonine, the joint pain was relieved, but the primary disease did not improve. Subsequently, there was no regular treatment. One year later, the disease recurred and was complicated with severe infection. Her condition improved following anti-infection and induction therapy.Conclusions:TTMV::RARA fusion gene-positive pediatric acute promyelocytic leukemia is a special type of acute promyelocytic leukemia caused by the insertion of viral sequences from TTMV infection. It is rare in clinical practice and difficult to treat, and the overall prognosis may be poor.
