Acute lymphoblastic leukemia secondary to Burkitt lymphoma in children: report of 1 case and review of literature
10.3760/cma.j.cn115356-20250210-00017
- VernacularTitle:儿童伯基特淋巴瘤继发急性淋巴细胞白血病1例并文献复习
- Author:
Chaorong WANG
1
;
Haijun WANG
;
Lechen LI
;
Nuoyan SHI
;
Luyue DING
;
Linlin LIU
;
Tianyou WANG
;
Wei LIU
;
Yanna MAO
;
Wei LIN
Author Information
1. 郑州大学附属儿童医院 河南省儿童医院急诊医学科，郑州 450018
- Keywords:
Leukemia, B lymphocytes;
Burkitt lymphoma;
Child;
Drug therapy, combination
- From:
Journal of Leukemia & Lymphoma
2025;34(8):489-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the understanding of acute lymphoblastic leukemia (ALL) secondary to Burkitt lymphoma (BL) in children.Methods:The clinical data of a child with ALL secondary to BL who was admitted to Children's Hospital Affiliated to Zhengzhou University in June 2024 were retrospectively analyzed, and the relevant literature was reviewed.Results:The patient was a boy with the age of 8 years and 8 months. He presented with a neck mass at the age of 4 years and 6 months, and pathological examination revealed a diagnosis of BL with clinical stage Ⅲ. The patient was given regular chemotherapy according to the Chinese Children's Lymphoma Group non-Hodgkin lymphoma mature B-cell 2017 protocol-B2 regimen. PET-CT showed recurrence of lymphoma in 6 months after the suspension of treatment. The patient was given with placement of 125I particles, oral etoposide and dexamethasone, and traditional Chinese medicine. The patient was admitted to hospital at the age of 8 years and 8 months with fever and skin hemorrhagic spots, bone marrow morphology, immunology, cytogenetics and molecular biology typing indicated a diagnosis of B-ALL with TCF3::PBX1 fusion gene. The patient received induction chemotherapy according to the Chinese Children's Leukemia Group-ALL 2018 protocol. A review of bone marrow cytology achieved complete remission on the 33rd day of chemotherapy, and minimal residual disease detected by flow cytometry indicated less than 0.01%. TCF3::PBX1 fusion gene was negative. Conclusions:ALL secondary to BL in children is rare, and the ALL treatment regimens are effective.
