Cellular mechanisms in cancer immunoediting
10.3760/cma.j.cn115356-20240918-00141
- VernacularTitle:癌症免疫编辑中的细胞机制
- Author:
Kefu WU
1
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所） 血液与健康全国重点实验室 国家血液系统疾病临床医学研究中心 细胞生态海河实验室，天津 300020
- Keywords:
Neoplasm;
Cancer immunoediting;
Immunogenic cell death;
Cellular senescence;
Neutrophil extracellular trap
- From:
Journal of Leukemia & Lymphoma
2025;34(5):284-290
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of tumors are determined by both intrinsic and microenvironmental factors. The components of the tumor microenvironment exhibit great heterogeneity resulting in either pro-tumor or anti-tumor effects. The deep exploration of tumor immune microenvironment gave birth to the hypothesis of cancer immunoediting, which is supported by more and more evidence. Cancer immunoediting is accomplished through the interactions among various cells and factors in the microenvironment. While many molecular mechanisms have been studied, the cellular mechanisms of cancer immunoediting have been paid attention. This article explores the roles of cellular mechanisms in the cancer immunoediting, including immunogenic cell death, cellular senescence and neutrophil extracellular trap. The elucidation of these mechanisms not only reveals the complexity of the pathogenesis and progression of tumors, but also provides new targets and prognostic indicators for the diagnosis and treatment of tumors.
