Role and therapeutic progress of clonal hematopoiesis of indeterminate potential in lymphoma

VernacularTitle:潜能未定的克隆性造血在淋巴瘤中的作用及治疗进展
Author: Qingqing LUO ¹ ; Zhixiang LEI ; Li YU
Author Information

1. 南昌大学第二附属医院血液内科，南昌　330006
Keywords: Clonal hematopoiesis of indeterminate potential; Lymphoma; Treatment; Prognosis
From: Journal of Leukemia & Lymphoma 2025;34(4):249-252
CountryChina
Language:Chinese
Abstract: Clonal hematopoiesis of indeterminate potential (CHIP) refers to the clonal expansion phenomenon of hematopoietic stem cells caused by gene mutations, which has been considered as a potential pathogenetic basis for various diseases. The latest research reveals a possible relationship between CHIP and lymphoma. This article summarizes and explores the role and mechanism of CHIP mediated by TET2 and DNMT3A in lymphoma, and reviews the treatment strategies targeting these genes and related inflammatory pathways, aiming to provide new ideas and methods for the treatment of lymphoma.