Progress of acute myeloid leukemia related gene mutations
10.3760/cma.j.cn115356-20240118-00010
- VernacularTitle:急性髓系白血病相关基因突变的研究进展
- Author:
Yunyun LI
1
;
Tao WU
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Keywords:
Leukemia, myeloid, acute;
Mutation;
Gene;
Next-generation sequencing;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2025;34(2):125-128
- CountryChina
- Language:Chinese
-
Abstract:
Acute myeloid leukemia (AML) is an aggressive malignant tumor with high heterogeneity. It is characterized by rapid proliferation, dysapoptosis and impaired differentiation of leukemic blast cells. It can develop at any age. The complexity of the etiology, the diversity of mechanisms, and the variability of cytogenetics and genomics hid behind the development and evolution of AML, among which some specific cytogenetic and genomic abnormalities cause the high recurrence rate and drug resistance rate of clinical AML patients. At present, the clinical application of mutated genes has become a hot field in clinical medicine. This paper reviews the role of common mutated genes and molecular targeted therapy in order to provide help for clinical treatment.
