Progress of drugs targeting the hypoxic microenvironment of leukemia
10.3760/cma.j.cn115356-20231210-00096
- VernacularTitle:靶向白血病缺氧微环境相关药物的研究进展
- Author:
Lijuan JING
1
;
Huixia WANG
;
Lili YANG
;
Haiying LI
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Keywords:
Leukemia;
Tumor microenvironment;
Hypoxic microenvironment;
Molecular targeted therapy
- From:
Journal of Leukemia & Lymphoma
2025;34(2):121-125
- CountryChina
- Language:Chinese
-
Abstract:
Leukemia is a malignant proliferative tumor that seriously endangers the quality of life of patients. In recent years, new research achievements have been made on the pathogenesis of leukemia, and some progresses of various drugs targeting the hypoxic microenvironment of leukemia have been made. This article reviews the progress of drugs targeting hypoxia microenvironment to treat leukemia from the aspects such as reactive oxygen species associated with anoxic microenvironment, hypoxia inducible factor, CXC chemokine receptor and vascular endothelial growth factor.
