Research progress in mechanism of podocyte injury and its potential therapeutic strategies for diabetic nephropathy
10.13481/j.1671-587X.20250531
- VernacularTitle:足细胞损伤机制及其治疗糖尿病肾病潜在策略的研究进展
- Author:
Xun LU
1
;
Chengxin MA
;
Jianan YANG
;
Xinxin GUO
;
Xiaobei XIE
;
Binghai ZHAO
;
Hongzhi LI
Author Information
1. 北华大学基础医学院吉林省肾脏病基因测序精准医疗创新中心,吉林吉林 132011
- Keywords:
Podocyte;
Injury mechanism;
Diabetic nephropathy;
Therapeutic target;
Renin-angiotensin-aldosterone system;
Mitochondrial damage
- From:
Journal of Jilin University(Medicine Edition)
2025;51(5):1415-1422
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy(DN)is a significant causative factor of end-stage renal disease globally,and its pathogenesis involves dysregulation of multiple cellular and hormonal pathways.Podocytes play crucial roles in the process of DN,with the extent of podocyte injury closely associated with key pathological manifestations of renal damage,such as proteinuria,glomerular filtration rate,and glomerulosclerosis.However,due to the complexity and interplay of mechanisms contributing to podocyte injury,such as oxidative stress,abnormal lipid metabolism,and mitochondrial damage,the precise mechanisms underlying podocyte injury remain incompletely understood.This review integrated the latest research findings from both domestic and international studies on the core mechanisms of podocyte injury in DN.Furthermore,this article summarized the implications of these mechanisms for DN treatment,particularly focusing on potential therapeutic targets and the development of related pharmacological interventions derived from targeting podocyte injury pathways,so as to provide a theoretical foundation for the development of clinical therapeutic strategies for DN.
