Research progress in MRI neuroimaging for patients with functional gastrointestinal diseases and inflammatory bowel disease
10.13481/j.1671-587X.20250230
- VernacularTitle:功能性胃肠道疾病和炎症性肠病患者核磁共振神经影像学的研究进展
- Author:
Fanjun SUN
1
;
Xingchen PAN
;
Dan TONG
Author Information
1. 吉林大学第一医院放射线科,吉林长春 130021
- Keywords:
Functional gastrointestinal diseases;
Inflammatory bowel disease;
Brain-gut axis;
Magnetic resonance imaging;
Neuroimaging
- From:
Journal of Jilin University(Medicine Edition)
2025;51(2):541-548
- CountryChina
- Language:Chinese
-
Abstract:
Functional gastrointestinal disease(FGID)and inflammatory bowel disease(IBD)are two common gastrointestinal diseases in clinical practice.FGID refers to non-structural changes in gastrointestinal function,with irritable bowel syndrome(IBS)and functional dyspepsia(FD)being the common types.On the other hand,IBD is a group of chronic inflammatory bowel diseases with well-defined pathological features,mainly including Crohn's disease(CD)and ulcerative colitis(UC).Over the past decades,the incidence rates of both FG1D and IBD have increased with years,accompanied by high recurrence rates,and the clinical outcomes remain unsatisfactory,which seriously affect the physical and mental health of patients.Further research has revealed that neuropsychiatric abnormalities,including mental and psychological disorders,play important roles in the occurrence and development of FGID and IBD.The comorbidity of gastrointestinal and psychiatric diseases shares a common pathophysiological basis,that is,the abnormalities in the bidirectional communication between the gut and the central nervous system,and the theory of brain-gut axis has emerged as a research hotspot in this field.Better therapeutic outcomes can be achieved by screening and identifying key brain regions closely related to FGID and IBD through quantifiable assessments,and implementing combined pharmacotherapy on both the digestive system and the nervous system based on the theory of brain-gut axis.Current neuroimaging studies have provided the preliminary results for understanding the changes in the nervous system in FGID and IBD patients,but there is still a lack of systematic evaluation of the application of neuroimaging studies based on the brain-gut axis in gastrointestinal diseases.This paper reviewed the changes in brain structure and function associated with FGID and IBD,and the neuroimaging-based analysis of the brain-gut axis theory in the occurrence and development of these diseases,in order to provide theoretical basis for future personalized precision medicine of FGID and IBD based on the brain-gut axis.
