Research progress in effect of phosphorylation modification of Hedgehog signaling pathway on occurrence and development of tumor
10.13481/j.1671-587X.20250228
- VernacularTitle:Hedgehog信号通路磷酸化修饰在肿瘤发生发展中作用的研究进展
- Author:
Xin ZHANG
1
;
Fei WANG
;
Bingjie CUI
;
Jing DU
Author Information
1. 滨州医学院附属医院医学研究中心,山东滨州 256603;滨州医学院第一临床医学院血液内科,山东滨州 256603
- Keywords:
Tumor;
Hedgehog signaling pathway;
Protein phosphatase;
Dephosphorylation
- From:
Journal of Jilin University(Medicine Edition)
2025;51(2):526-533
- CountryChina
- Language:Chinese
-
Abstract:
The Hedgehog(HH)signaling pathway is involved in various developmental processes of vertebrates and invertebrates,including embryogenesis,stem cell renewal,tissue regeneration,the occurrence and development of tumor and chemotherapy resistance.Overactivation and abnormal expression of key components in the HH signaling pathway are associated with the development of various malignant tumors.Phosphorylation plays an important role in regulating the activity and function of proteins in normal cells,and the disorder of phosphorylation-dephosphorylation cascade is closely related to tumorigenesis.The abnormal activation of this signaling pathway is also related to protein phosphorylation,while its complex underlying mechanism needs to be further explored.This article reviewed the research progress of the HH signaling pathway and protein phosphorylation modification in malignant tumors,focusing on the regulatory effect of phosphorylation modification on the activity of HH signaling pathway and its effect on the occurrence and development of malignant tumors,in order to provide a theoretical basis for the in-depth development and clinical application of targeted drugs for phosphatase/dephosphatase.
