Changes in levels of inflammatory factors in gingival crevicular fluid of patients with periodontal disease before and after invisible appliance:A Meta-analysis
10.13481/j.1671-587X.20250122
- VernacularTitle:牙周病患者隐形矫治器治疗前后龈沟液中炎性因子水平变化的Meta分析
- Author:
Yinxia TAI
1
;
Han ZHANG
;
Lei YU
;
Xianchun ZHU
Author Information
1. 吉林大学口腔医院正畸科,吉林 长春 130021
- Keywords:
Periodontal disease;
Invisible appliance;
Fixed appliance;
Meta-analysis;
Inflammatory factors
- From:
Journal of Jilin University(Medicine Edition)
2025;51(1):182-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the changes in the levels of inflammatory factors in gingival crevicular fluid of the patients with periodontal disease underwent invisible appliance,and to provide the reference for clinical practice.Methods:PubMed,Embase,Cochrane Library,China National Knowledge Infrastructure(CNKI),Chinese Biology Medicine(CBM),Wanfang and VIP Databases were used for literature collection about the treatment using invisible appliance and fixed appliance for periodontal disease.The retrieval time was limited from January 1997 to November 2023.Two researchers independently screened the literatures and extracted data based on the inclusion and exclusion criteria,and conducted quality evaluation.Review Manager 5.4 software was used to analyze the changes in the levels of inflammatory cytokines including tumor necrosis factor-α(TNF-α),C-reaction protein(CRP),interleukin-6(IL-6),interleukin-1β(IL-1β)and interleukin-2(IL-2)before and 6 months after appliance placement.Results:Six randomized controlled trials were included in this study with a total sample size of 601 cases.Subgroup analysis was conducted based on the type of brackets.The results of Meta-analysis showed that compared with fixed appliance group,the changes in the levels of TNF-α(MD=-1.32,95％CI:-1.87--0.77,P＜0.001),IL-6(MD=-0.78,95％CI:-1.22--0.35,P＜0.001),CRP(MD=-1.03,95％CI:-1.30--0.76,P＜0.001)and IL-1β(MD=-1.45,95％CI:-2.21--0.70,P＜0.001)in invisible appliance group were significantly decreased,while the change in IL-2 level(MD=0.74,95％CI:0.61-0.87,P＜0.001)was significantly increased.Conclusion:Compared with fixed appliance,the invisible appliance can better control the levels of inflammatory factors in gingival crevicular fluid of the patients with periodontal disease,which is beneficial to the periodontal tissue health of these patients.
