Clinical evaluation and management of checkpoint inhibitor pneumonitis with advanced biliary tract cancer: a report of 3 cases
10.16139/j.1007-9610.2025.06.10
- VernacularTitle:胆道恶性肿瘤晚期免疫检查点抑制剂相关性肺炎的临床评估和处理（附3例报告）
- Author:
Xueying SUN
;
Bin WU
;
Yifei JIANG
;
Zhuojun LIAO
;
Jinyan ZHAO
;
Ying ZHOU
;
Shulong ZHANG
;
Yan WANG
;
Houbao LIU
- Publication Type:Journal Article
- From:
Journal of Surgery Concepts & Practice
2025;30(6):517-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report cases of checkpoint inhibitor pneumonitis （CIP） in patients with advanced biliary tract cancer, aiming to provide additional approaches for the assessment, treatment, and monitoring of this condition. Methods Three patients developed oxygen desaturation and interstitial lung lesions during chemotherapy combined with immunotherapy, and were diagnosed with CIP in collaboration with the respiratory department. Antitumor therapy was discontinued in the acute phase, and glucocorticoids were administered, with regular monitoring of disease progression. During follow-up, case 1 developed lung metastasis; case 2 showed improvement; case 3 had concurrent infection and tumor progression. Results Glucocorticoids improved lung lesions and hypoxic symptoms in patients with CIP, but attention should be paid to the potential for concurrent infections and tumor progression. Conclusions Comprehensive assessment and early identification of CIP are crucial for patients with advanced biliary tract cancer. For those with recurrent symptoms after glucocorticoid therapy, timely and accurate adjustment of the treatment regimen is essential.
