Characteristics of cyst fluid can predict the benign or malignant nature of intraductal papillary mucinous neoplasms
10.16139/j.1007-9610.2025.06.09
- VernacularTitle:囊液性状可预测胰腺导管内乳头状黏液性肿瘤的良、恶性
- Author:
Jingyuan WANG
;
Jiayu FAN
;
Pingping ZHANG
;
Hongyun MA
;
Ying CHEN
;
Gang LI
;
Zhendong JIN
;
Gang JIN
;
Kaixuan WANG
- Publication Type:Journal Article
- From:
Journal of Surgery Concepts & Practice
2025;30(6):509-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive ability of cyst fluid characteristics for malignant intraductal papillary mucinous neoplasms (IPMNs). Methods We prospectively collected fresh cyst fluid from patients undergoing pancreatic resection at the Department of Hepatobiliary Pancreatic Spleen Surgery, Changhai Hospital, Shanghai, from September 2023 to December 2024, who were ultimately pathologically confirmed with IPMN. We assessed the characteristics of cyst fluid, including viscosity, clarity, and color, and explored its predictive performance for benign or malignant. Results A total of 40 patients with IPMN were included. The sensitivity of the string sign （+） for diagnosing high-grade dysplasia/ invasive carcinoma （HGD/IC） was 90.9%, specificity was 92.9%, and accuracy was 76.0%. The cyst fluid of intestinal-type IPMN often exhibited a gelatinous consistency, and there was no significant difference in the distribution of gelatinous consistency between the HGD/IC group and the low-grade dysplasia （LGD） group. There were no significant differences in CEA, glucose, and amylase levels in the cyst fluid between the HGD/IC group and the LGD group. Conclusions The characteristics of pancreatic cyst fluid, especially viscosity, can effectively predict the benign or malignant nature of IPMN.
