Reflections on key issues in neoadjuvant therapy for pancreatic cancer: a paradigm shift from evidence-based medicine to precision medicine
10.16139/j.1007-9610.2025.06.03
- VernacularTitle:胰腺癌新辅助治疗若干问题思考：从循证医学到精准医疗的范式转换
- Author:
Xiaochao KANG
;
Yikai LI
;
Shiwei GUO
;
Gang JIN
- Publication Type:Journal Article
- From:
Journal of Surgery Concepts & Practice
2025;30(6):474-478
- CountryChina
- Language:Chinese
-
Abstract:
Neoadjuvant therapy for pancreatic cancer is undergoing a paradigm shift from conventional chemotherapy to precision medicine. This expert forum discussed cutting-edge issues in pancreatic cancer neoadjuvant therapy from an evidence-based perspective, incorporating the latest clinical research advances. We focused on innovative directions including immunotherapy combination strategies, liquid biopsy applications, artificial intelligence (AI)-assisted decision making, and individualized precision medicine. We proposed forward-looking concepts such as molecular subtyping-guided individualized treatment strategies, multi-omics integrated efficacy prediction models, and standardized multidisciplinary collaborative care systems. These innovative concepts will drive pancreatic cancer neoadjuvant therapy toward more precise and effective directions.
