Application of GLP-1 receptor agonists in postoperative combined therapy for obesity: a perspective of metabolic surgery

VernacularTitle:代谢外科视角下GLP-1受体激动剂在肥胖症术后联合治疗中的应用
Author: Hua MENG ; Yujia SONG ; Siqi WANG
Publication Type:Journal Article
From: Journal of Surgery Concepts & Practice 2025;30(3):207-213
CountryChina
Language:Chinese
Abstract: The global prevalence of obesity continues to rise, accompanied by various metabolic complications. While metabolic surgery has significant efficacy, there are still problems, such as suboptimal clinical outcomes and recurrent weight gain. The superior metabolic regulatory of glucagon-like peptide-1 (GLP-1) receptor agonists has made them a new option for bariatric treatment. This article systematically explored the clinical application framework of combining metabolic surgery with GLP-1 receptor agonists, including target populations (e.g., patients with postoperative weight regain, unremitted diabetes, or comorbid complications), intervention timing, drug selection strategies, and multidisciplinary collaboration pathways. Although combination therapy holds broad prospects, it still faces challenges, such as optimal treatment strategies, long-term safety, and cost-effectiveness. We should emphasize multidisciplinary collaboration and individualized plans to optimize the long-term effective management of obesity in the future.