Current status of research on the mechanism of action of emodin in the prevention and treatment of chronic liver diseases
- VernacularTitle:大黄素防治慢性肝病作用机制的研究现状
- Author:
Yajie CHEN
1
;
Xin WANG
1
;
Yunjuan WU
1
;
Ying SU
1
;
Yuhan WANG
2
;
Jinxue ZHANG
1
;
Ning YAO
3
;
Ying QIN
1
;
Xiaoning ZUO
1
Author Information
- Publication Type:Review
- Keywords: Emodin; Liver Diseases; Signal Transduction
- From: Journal of Clinical Hepatology 2026;42(1):228-234
- CountryChina
- Language:Chinese
- Abstract: Chronic liver diseases are a group of diseases in which the liver is subjected to a variety of injuries over a long period of time， resulting in irreversible pathological changes that last longer than 6 months. Emodin （EMO） is a natural anthraquinone derivative derived from Rheum officinale， and its pharmacological effect has been extensively studied， exhibiting a variety of biological properties and involving multiple signaling molecules and pathways. Western medicine or surgical treatment is currently the main treatment regimen for chronic liver diseases， and the advance in treatment is limited by various reasons such as side effects and high costs. Due to its natural origin and efficacy， EMO has unique advantages in the treatment of chronic liver diseases and has now become a research hotspot. This article summarizes the therapeutic effect of EMO on chronic liver diseases and its mechanism， in order to provide a certain scientific basis for the traditional Chinese medicine treatment of chronic liver diseases and the development of drugs in clinical practice.
