Role of pyroptosis in hepatic fibrosis and related research advances
- VernacularTitle:细胞焦亡在肝纤维化中的作用及研究进展
- Author:
Yongfan JIN
1
;
Chunmei ZHAO
1
;
Wenlin TAI
1
Author Information
- Publication Type:Review
- Keywords: Pyroptosis; Hepatic Fibrosis; Inflammasome
- From: Journal of Clinical Hepatology 2026;42(1):197-202
- CountryChina
- Language:Chinese
- Abstract: Hepatic fibrosis is not only a pathological process of hepatic self-repair after chronic liver injury， but also a critical stage in the progression of chronic liver disease to liver cirrhosis. Studies have shown that as a pro-inflammatory form of programmed cell death， pyroptosis plays an important role in various diseases and is also considered a potential therapeutic target for hepatic fibrosis. This article systematically reviews the association of pyroptosis in hepatocytes， hepatic stellate cells， and hepatic macrophages with hepatic fibrosis and discusses pyroptosis-mediated therapeutic strategies targeting hepatic fibrosis.
