Research advances in mitochondrial dysfunction in the pathogenesis of hepatic fibrosis

Yudie HONG; Jinchen GUO; Weibing SHI; Yujie SUN; Jiamin WANG; Tiantian GAO

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Research advances in mitochondrial dysfunction in the pathogenesis of hepatic fibrosis

VernacularTitle:线粒体功能障碍在肝纤维化发病中的作用机制
Author: Yudie HONG ¹ ; Jinchen GUO ² ; Weibing SHI ¹ ; Yujie SUN ¹ ; Jiamin WANG ¹ ; Tiantian GAO ¹
Author Information

1. Department of Hepatology， The First Affiliated Hospital School of Anhui University of Chinese Medicine， Hefei 230031， China
2. College of Traditional Chinese Medicine， Anhui University of Chinese Medicine， Hefei 230012， China
Publication Type:Review
Keywords: Hepatic Fibrosis; Mitochondria; Pathologic Processes
From: Journal of Clinical Hepatology 2026;42(1):190-196
CountryChina
Language:Chinese
Abstract: Hepatic fibrosis refers to excessive accumulation and abnormal proliferation of fibrous connective tissue in the liver triggered by multiple pathogenic factors， and it may progress to liver cirrhosis， portal hypertension， and liver cancer. The pathological mechanisms of hepatic fibrosis involve hepatocyte injury， inflammatory cell infiltration with the release of inflammatory mediators， hepatic stellate cell activation， and extracellular matrix deposition. Recent studies have focused on mitochondrial dysfunction in disease progression， including the molecular pathways for hepatic fibrosis driven by metabolic disorders， energy deficiency， oxidative stress， mitochondrial dynamic imbalance， and autophagic dysfunction， all of which can induce liver injury. This article reviews the latest advances in hepatic fibrosis， in order to provide new therapeutic strategies for clinical management.