Role and mechanism of myeloid cells in hepatic fibrosis
- VernacularTitle:髓系细胞在肝纤维化中的作用及其机制
- Author:
Chengjie CUI
1
;
Zhenzhen ZHAO
1
;
Jing CUI
1
;
Shuxian ZANG
1
;
Na FU
1
Author Information
- Publication Type:Review
- Keywords: Hepatic Fibrosis; Myeloid Cells; Mechanism
- From: Journal of Clinical Hepatology 2026;42(1):183-189
- CountryChina
- Language:Chinese
- Abstract: Hepatic fibrosis is a complex dynamic process caused by multiple chronic pathogenic factors， characterized by excessive accumulation of liver extracellular matrix and abnormal liver structure and function. If anti-fibrotic treatment is not performed in time， it can progress to liver cirrhosis and even liver cancer. Hepatic fibrosis has a complex pathogenesis， and previous studies mainly focused on the activation of hepatic stellate cells. Recent studies have shown that myeloid cells have the potential of multi-directional differentiation and can also participate in the development and progression of hepatic fibrosis. This article systematically reviews the role and regulatory mechanism of myeloid cells in hepatic fibrosis， in order to provide a reference for clinical diagnosis and targeted therapy.
