Treatment strategies for chronic hepatitis B based on covalently closed circular DNA dynamics
- VernacularTitle:基于共价闭合环状DNA动力学的慢性乙型肝炎治疗策略
- Author:
Jieli HU
1
;
Ailong HUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Hepatitis B Virus; Covalently Closed Circular DNA; Therapeutics
- From: Journal of Clinical Hepatology 2026;42(1):14-20
- CountryChina
- Language:Chinese
- Abstract: Cure of chronic hepatitis B virus （HBV） infection is the ultimate goal in HBV-related research， and exploring potential curative pathways may help to identify key research directions. Covalently closed circular DNA （cccDNA）， as the most difficult genetic material to be eliminated within the HBV replication cycle， is not only a primary impediment to achieving cure， but also a key issue for establishing an analytical framework for cure strategies. This article reviews the thinking framework of “cccDNA dynamics”， further elaborates on its core implications， and systematically discusses the main strategies to promote cccDNA decay.
