TCM Treatment of Sarcopenia Based on PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20251492
- VernacularTitle:基于PI3K/Akt信号通路探讨中医药治疗肌肉减少症的研究进展
- Author:
Yan CHEN
1
;
Ting DAI
1
;
Changsheng GUO
2
;
Zhihai FENG
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2. Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
sarcopenia;
phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway;
monomer of traditional Chinese medicine;
extract of traditional Chinese medicine;
compound formula of traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(6):316-326
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is a systemic skeletal muscle disease characterized by the gradual decline of muscle mass，strength，and function，and its occurrence and development are related to multiple factors，involving several signaling pathways. Among them，the phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） signaling pathway，as a key pathway regulating cellular growth，survival，and metabolism，plays an important role in the formation and development of sarcopenia. Its abnormal activation or deactivation may lead to an imbalance in muscle protein metabolism，resulting in muscle atrophy and reduction. Modern medicine is still in the exploratory stage of treatment for sarcopenia. Traditional Chinese medicine （TCM），with its multi-pathway and multi-target characteristics，has shown increasing advantages in the prevention and treatment of sarcopenia. In recent years，various monomers， extracts，and compound formulas of TCM have been proven to effectively prevent and treat sarcopenia by promoting muscle cell protein synthesis，reducing protein degradation，inhibiting cell apoptosis and inflammatory response，and improving mitochondrial function. This paper reviewed the improvement effects of TCM on sarcopenia based on the PI3K/Akt pathway and explored its specific action mechanisms， aiming to provide new insights for the treatment of sarcopenia with TCM.
