Traditional Chinese Medicine in Treatment of Chronic Atrophic Gastritis by Regulating PI3K/Akt Signaling Pathway：A Review
10.13422/j.cnki.syfjx.20252394
- VernacularTitle:中医药调控PI3K/Akt信号通路治疗慢性萎缩性胃炎的研究进展
- Author:
Yuxue DING
1
;
Zhiwei SU
1
;
Juan XUE
2
;
Jun SUN
2
;
Chunyan JI
1
Author Information
1. Hubei University of Chinese Medicine，Wuhan 430065，China
2. Hubei Provincial Hospital of Integrated Chinese and Western Medicine，Wuhan 430015，China
- Publication Type:Journal Article
- Keywords:
phosphatidylinositol 3-kinase（PI3K）/protein kinase B（Akt） signaling pathway;
chronic atrophic gastritis（CAG）;
traditional Chinese medicine;
multi-target regulation;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(6):307-315
- CountryChina
- Language:Chinese
-
Abstract:
Chronic atrophic gastritis （CAG） is a digestive system disease characterized by the reduction and atrophy of the intrinsic glands of the gastric mucosa. This disease is closely related to risk factors such as Helicobacter pylori （Hp） infection，long-term unhealthy eating habits and lifestyle. As CAG is a key link in the development of gastric cancer，effectively preventing its deterioration is of great significance for the prevention of gastric cancer. At present，Western medicine mainly uses symptomatic treatments such as eradicating Hp，protecting gastric mucosa， and promoting gastrointestinal motility. However， long-term use is prone to drug resistance and cannot reverse limitations such as gland atrophy， making it urgent to explore new intervention strategies. In recent years，with the deepening of CAG mechanism research，the phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway，as one of the classic signaling pathways，plays a significant role in the occurrence and development of CAG，while its systematic summary is still blank. Based on the regulatory advantages of "multi-target，multi-pathway，and low toxicity"，traditional Chinese medicine can improve the pathological process of CAG by intervening in key nodes of the PI3K/Akt pathway. In this paper，the research progress of traditional Chinese medicine regulating PI3K/Akt pathway to improve CAG was systematically reviewed for the first time. The expression of PI3K/Akt signaling pathway in CAG was discussed，including the regulation of inflammation and oxidative stress，cell proliferation and apoptosis，and autophagy. The traditional Chinese medicine flavonoids，alkaloids，terpenoids and other compounds that regulate this pathway were summarized. The traditional Chinese medicine compounds mainly include classic famous prescriptions such as Xiaochaihu Tang，Banxia Xiexin Tang，Morodan concentrated pills，Elian granules and other traditional Chinese patent medicines，as well as empirical prescriptions such as modified Leweiyin formula，and Qiling prescription. This study aims to give full play to the advantages of traditional Chinese medicine and lay a solid foundation for the wide application and further development of CAG treatment，and provide new ideas for clinical research and drug research on CAG.
