Rehmanniae Radix Preparata in Common Central Nervous System Diseases： A Review
10.13422/j.cnki.syfjx.20252008
- VernacularTitle:熟地黄在常见中枢神经系统疾病的研究进展
- Author:
Miao LIANG
1
;
Lihua CHEN
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine （Ministry of Education）， Jiangxi University of Chinese Medicine，Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
Rehmanniae Radix Preparata;
central nervous system disease;
research progress;
active component;
action mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(6):286-296
- CountryChina
- Language:Chinese
-
Abstract:
Central nervous system diseases refer to complex disorders that affect the structure and function of the central nervous system （brain and spinal cord）. Due to their complex pathogenesis and the lack of effective therapies， the diseases have become one of the leading causes of human death and have imposed a heavy economic burden on families and society. Rehmanniae Radix Preparata， a representative traditional Chinese medicine for "nourishing essence and enriching marrow"， has multi-target and multi-pathway advantages in the treatment of central nervous system diseases. It contains various active components such as catapol， verbascoside， and echinacoside and has multiple pharmacological effects including anti-depression， neuroprotection， antioxidation， anti-inflammation， and immunomodulation. In Alzheimer's disease， Rehmanniae Radix Preparata can regulate the processing of beta-amyloid precursor protein to reduce its production， and its antioxidative and neuroprotective effects can alleviate related pathological damage. In Parkinson's disease， it can protect dopaminergic neurons by regulating intracellular signal transduction pathways. In ischemic stroke， its antioxidative， anti-inflammatory， and neuroprotective effects can alleviate pathological reactions. Multiple sclerosis is an autoimmune demyelinating disease， and its pathogenesis is related to the autoimmune response attacking the myelin sheath of the central nervous system. The anti-inflammatory effect of Rehmanniae Radix Preparata can help inhibit this autoimmune response， reduce the damage of inflammation to the myelin sheath， and protect damaged neurons while promoting myelin sheath repair. In depression， Rehmanniae Radix Preparata can improve neural plasticity， and its anti-inflammatory effect can regulate neuroendocrine function and influence the metabolism of neurotransmitters. This paper explored the action mechanism of Rehmanniae Radix Preparata in central nervous system diseases and summarized the relevant basic research and research progress on its active components and traditional Chinese medicine formulas for treating central nervous system diseases， providing a theoretical basis for the development of traditional Chinese medicine products for the prevention and treatment of central nervous system diseases with Radix Rehmanniae Preparata.
