Treatment of Idiopathic Pulmonary Fibrosis from Impediment
10.13422/j.cnki.syfjx.20250928
- VernacularTitle:从“痹”论治特发性肺纤维化的研究进展
- Author:
Siyu CHEN
1
;
Zhenghua CAO
1
;
Rong XU
1
;
Qingrong LI
1
;
Yanze BI
1
;
Boyi SHANG
1
;
Shaodan HU
2
Author Information
1. Changchun University of Chinese Medicine， Changchun 130117，China
2. The Affiliated Hospital of Changchun University of Chinese Medicine， Changchun 130000，China
- Publication Type:Journal Article
- Keywords:
idiopathic pulmonary fibrosis （IPF）;
lung impediment;
dredging and replenishing lung collaterals;
collateral disease theory;
biological mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(6):254-264
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis （IPF） is a chronic and fibrotic lethal interstitial lung disease with poor prognosis. It is mainly treated by organ transplantation and administration of chemical drugs， which have poor efficacy and induce side effects， failing to meet the clinical needs. Therefore， it is urgent to develop more safe and effective drugs to treat IPF. Traditional Chinese medicine （TCM） has garnered increasing attention in recent years in the treatment of IPF due to its unique advantages. Increasing studies have shown that TCM has remarkable therapeutic effects on IPF and thus demonstrate broad application prospects. Modern medical research shows that the pathogenesis of IPF can be discussed from inflammation （macrophage polarization）， oxidative stress， epithelial-mesenchymal transition （EMT）， autophagy inhibition and other related signaling pathways， while few studies systematically explain the relationship between the signaling pathways and TCM theory. According to the theory of TCM， lung collateral obstruction is the basic pathogenesis of IPF. Therefore， according to the principle of dredging and replenishing lung collaterals， IPF can be treated with the methods of reinforcing healthy qi and eliminating pathogen， replenishing qi and activating blood， and detoxifying and dredging collaterals， which demonstrate definite curative effect and can effectively relieve clinical symptoms， restore the lung function and blood oxygen partial pressure， improve the quality of life of patients， and reduce adverse reactions. Experimental studies have found that dredging and replenishing lung collaterals have significant effects on IPF inflammation （macrophage polarization）， oxidative stress， EMT， autophagy inhibition and other signaling pathways. Therefore， from the perspective of impediment， this article reviews pathogenesis of IPF， the research progress in TCM treatment of IPF， and the treatment of IPF from active components， single herbs， and compound prescriptions of TCM， with the aim of revealing the scientific connotation of the treatment of IPF from impediment and providing a new theoretical basis for enriching the TCM methods of treating IPF.
