Etiology and Pathogenesis， Syndrome Differentiation and Treatment， and Medication Rules of Diabetic Kidney Disease
10.13422/j.cnki.syfjx.20260336
- VernacularTitle:糖尿病肾病中医病因病机、辨证论治及用药规律分析
- Author:
Fengfeng ZHANG
1
;
Qianwen YANG
2
;
Yexin CHEN
2
;
Yingchao WANG
3
;
Zongjiang ZHAO
2
Author Information
1. Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China
2. Beijing University of Chinese Medicine， Beijing 100029， China
3. Beijing Aerospace General Hospital， Beijing 100007， China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
etiology;
pathogenesis;
stage-specific differentiation and treatment;
medication rule
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(6):246-253
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is one of the most common microvascular complications of diabetes. Traditional Chinese medicine （TCM） plays a unique role in improving clinical symptoms， reducing proteinuria， and delaying the initiation of dialysis. Over time， scholars have held diverse views on the etiology， pathogenesis， and treatment strategies of DKD. This paper systematically reviews the etiology and pathogenesis， syndrome differentiation and treatment， and medication rules of DKD， aiming to provide a reference for clinical practice. Regarding etiology， DKD is closely related to insufficient innate endowment， improper diet， emotional disorders， overexertion， and prolonged diabetes. Its pathogenesis evolves dynamically. Specifically， early stage is characterized by Yin deficiency with dryness-heat and subtle discharge. Middle stage involves both Qi and Yin deficiency with dampness and blood stasis. Late stage presents Yin and Yang deficiency with intrinsic turbidity toxins. Blood stasis and sugar toxicity are the core pathological factors， persisting throughout the disease course and accelerating renal collateral damage and fibrosis. In terms of diagnosis and treatment， contemporary scholars advocate stage-specific treatment， emphasize the integration of prevention and therapy， recommend whole-course management， and support comprehensive TCM and Western medicine approaches. Analysis of medication rules shows that treatment consistently addresses the core principle of deficiency at the root and excess at the surface， strengthens the body while dispelling pathogenic factors， emphasizes promoting blood circulation and removing blood stasis， consolidates the kidney and astringes essence， clears Fu-organs and eliminates turbidity and toxins， invigorates the spleen， replenishes Qi， protects the stomach， and advocates treatment based on pathogenic wind. Further refinement of the academic thoughts of classical TCM masters and research into innovative pathogenesis theories and clinically effective prescriptions are needed to enhance TCM's ability to prevent and treat major clinical diseases， including DKD.
