Progress in the role of delta opioid receptor agonists in disease treatment
10.19405/j.cnki.issn1000-1492.2025.05.026
- VernacularTitle:δ阿片受体激动剂在疾病治疗中的新进展
- Author:
Fanghao Guo
1
;
Lesha Zhang
2
Author Information
1. The First Clinical School of Medicine , Anhui Medical University , Hefei 230032
2. Dept of Basic Medicine , Anhui Medical University , Hefei 230032
- Publication Type:Journal Article
- Keywords:
DOR agonists;
ischemia/reperfusion injury;
myocardial infarction;
sepsis;
Parkinson ’s disease;
de_ pression
- From:
Acta Universitatis Medicinalis Anhui
2025;60(5):970-975
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Opioids are commonly used drugs in the clinic, mainly targeting different subtypes of opioid receptors distributed in central and peripheral neurons. They are the preferred drugs for treating acute pain or cancer pain. Delta opioid receptor(DOR) agonists are opioid drugs that target the delta opioid receptor. In recent years, they have received widespread attention due to their ability to improve ischemia/reperfusion injury in multiple organs such as the heart, brain, and liver, as well as their potential for treating mental and neurological disorders. This review summarizes the mechanism research of DOR agonists in treating a variety of diseases, prospects their clinical application prospects, and finds that DOR agonists may exert anti-ischemia/reperfusion injury effects on organs by reducing apoptosis and mitochondrial damage, and activating various signaling pathways; they also exhibit anti-inflammatory, antidepressant, and therapeutic effects on neurodegenerative diseases, providing a new perspective for the application of DOR agonists in treating related diseases.
- Full text:2026020516073686139δ阿片受体激动剂在疾病治疗中的新进展_郭方豪.pdf
