Research advances in brain aging and brain age prediction in a high-altitude hypoxic environment
10.19845/j.cnki.zfysjjbzz.2026.0016
- VernacularTitle:高原低氧环境下脑老化脑龄预测研究进展
- Author:
Shuo WANG
1
;
Weizhong JI
1
Author Information
1. 青海大学研究生院， 青海 西宁 810016
- Publication Type:Journal Article
- Keywords:
Brain aging;
Brain age prediction;
Neuroimaging;
High altitudes;
Hypoxia
- MeSH:
Neuroimaging
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(1):92-96
- CountryChina
- Language:Chinese
-
Abstract:
With the acceleration of global population aging， the assessment and prediction of brain aging have become an important research direction in neuroscience. Brain age， as an indicator for measuring the biological age of the brain， can be used to assess individual cognitive function and predict the risk of neurodegenerative diseases. Neuroimaging techniques can reveal the structure and functional state of the brain， providing an important basis for brain age prediction. The hypoxic environment at high altitudes may accelerate brain aging， and its neuroimaging features provide a unique perspective for assessing brain aging. This article reviews the latest research advances in brain aging and brain age prediction under a high-altitude hypoxia environment， with a focus on the construction of brain age prediction models， the application of sMRI/DTI/fMRI， and the impact of high-altitude hypoxia on brain structure， function， and mechanisms， in order to provide a reference and directions for future research.
- Full text:2026020510375434234高原低氧环境下脑老化脑龄预测研究进展.pdf
