Research advances in the expression and regulation of non-coding RNAs in ischemic stroke
10.19845/j.cnki.zfysjjbzz.2026.0015
- VernacularTitle:非编码RNA在缺血性脑卒中的表达与调控研究进展
- Author:
Shuo ZHANG
1
;
Hongna YIN
2
Author Information
1. 黑龙江中医药大学， 黑龙江 哈尔滨 150040
2. 黑龙江中医药大学附属第二医院， 黑龙江 哈尔滨 150001
- Publication Type:Journal Article
- Keywords:
Non-coding RNA;
Ischemic stroke;
microRNA;
Review
- MeSH:
Review
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(1):85-91
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a cerebrovascular disease with high incidence and disability rates. Non-coding RNAs， as important regulatory factors for gene expression， play a key role in the development and progression of ischemic stroke， but their specific mechanisms of action remain unclear. This article systematically reviews the expression characteristics and regulatory roles of microRNAs， long non-coding RNAs， and circular RNAs in ischemic stroke and reveals the pathophysiological mechanisms of non-coding RNAs in ischemic injury by regulating the processes of cell apoptosis and autophagy， inflammatory response， blood-brain barrier integrity， and neuroregeneration. In addition， non-coding RNAs have shown the potential as biomarkers for the prediction， diagnosis， and prognostic evaluation of ischemic stroke. This article also analyzes the limitations of current research and proposes future research directions， so as to provide a theoretical foundation for exploring the mechanism of action of non-coding RNAs in ischemic stroke and developing innovative diagnostic and therapeutic strategies.
- Full text:2026020510333194978非编码RNA在缺血性脑卒中的表达与调控研究进展.pdf
