Association of endothelin-1/nitric oxide system activation with neurological function and cerebral blood flow after interventional surgery for cerebral infarction
10.19845/j.cnki.zfysjjbzz.2026.0010
- VernacularTitle:内皮素-1/NO系统活化与脑梗死介入术后神经功能和脑血流的关系
- Author:
Heng CHEN
1
Author Information
1. Department of Neurology， Changzhi People’s Hospital， Changzhi 046000， China
- Publication Type:Journal Article
- Keywords:
Endothelin-1;
Nitric oxide;
Cerebral infarction;
Interventional surgery;
Neurological function;
Cerebral blood flow
- MeSH:
Endothelin-1
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(1):60-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the endothelin-1/nitric oxide （ET-1/NO） system in neurological function and cerebral hemodynamics after interventional surgery for cerebral infarction， as well as the association of the levels of ET-1 and NO with neurological recovery and cerebral blood flow after surgery. Methods A total of 108 patients with cerebral infarction who were treated in our hospital from January 2022 to June 2023 were enrolled， and serum samples were collected before surgery and on day 30 after surgery. ELISA was used to measure the levels of ET-1 and NO；National Institutes of Health Stroke Scale（NIHSS） was used to assess neurological function； transcranial Doppler was used to measure cerebral hemodynamic parameters， including mean blood flow velocity， peak systolic velocity， and pulsatility index. A Spearman correlation analysis was used to investigate the correlation of ET-1 and NO with neurological function and cerebral hemodynamics，and the receiver operating characteristic （ROC） curve was used to assess the value of ET-1 and NO in predicting poor neurological function. Results After interventional surgery， there was a significant reduction in the level of ET-1 and a significant increase in the level of NO（both P<0.001）. The patients were divided into good recovery group （NIHSS≤5） and poor recovery group.Compared with the poor recovery group， the good recovery group had a significant reduction in serum ET-1 and a significant increase in serum NO （both P<0.001）. The Spearman correlation analysis showed that the serum level of ET-1 was negatively correlated with neurological recovery and the improvement in cerebral hemodynamics， while the level of NO was positively correlated with these two indicators. The ROC curve analysis showed that ET-1 and NO could effectively predict poor neurological recovery after interventional surgery， with an area under the ROC curve of 0.881 and 0.981，respectively. Conclusion The ET-1/NO system plays an important role in neurological function and cerebral hemodynamics after interventional surgery for cerebral infarction. Reducing ET-1 and increasing NO can facilitate the recovery of neurological function and cerebral blood flow after surgery. The levels of ET-1 and NO can be used as biomarkers for predicting poor postoperative neurological function and provide a scientific basis for optimizing postoperative treatment strategies.
- Full text:2026020510093202042内皮素-1_NO系统活化与脑梗死介入术后神经功能和脑血流的关系.pdf
