Molecular mechanisms and clinical therapeutic advances in lung cancer liver metastasis
10.19405/j.cnki.issn1000-1492.2025.05.003
- Author:
Pengcheng Ji
1
;
Yuanzi Ye
2
;
Changchun Shao
3
Author Information
1. Dept of Oncology , The First Afiliated Hospital of Anhui Medical University , Hefei 230022 ; Graduate School of Anhui University of Chinese Medicine , Hefei 230038
2. Dept of Pathology , The First Afiliated Hospital of Anhui Medical University , Hefei 230022
3. Dept of Oncology , The First Afiliated Hospital of Anhui Medical University , Hefei 230022 ;
- Publication Type:Review
- From:
Acta Universitatis Medicinalis Anhui
2025;60(5):783-787
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Liver metastasis is one of the most common complications of advanced lung cancer and an important factor influencing patient prognosis and survival. Currently, there are limited effective treatment options for lung cancer patients with liver metastasis, leading to short survival and poor prognosis. In-depth studies of the related molecular mechanisms are crucial for advancing clinical translation and optimizing therapeutic strategies. In recent years, more and more studies of the mechanisms of liver metastasis in lung cancer have performed, particularly in areas such as the roles of different proteins, cell-cell interactions, and changes in the tumor microenvironment. This review summarizes the current understanding of the basic process of lung cancer liver metastasis, regulatory proteins, signaling pathways, tumor microenvironment changes, and clinical treatment progress. Emerging evidence highlights the critical involvement of TGF-β/smad signaling pathway and integrin family proteins in promoting lung cancer liver metastasis. In the tumor microenvironment, various cell types including mononuclear phagocytes, fibroblasts, and hepatocytes contribute to this metastatic process. Clinically, the combination of immunotherapy with chemotherapy, radiotherapy, and antiangiogenic therapy has shown potential to improve treatment outcomes. Furthermore, targeted therapy against specific pathways, proteins, and cells within the tumor microenvironment, as well as the integration of multiple treatment modalities, holds promise for becoming effective strategies in the future clinical management of lung cancer liver metastasis.
- Full text:2026020510025120826肺癌肝转移的分子机制研究和临床治疗进展_季鹏程.pdf
