A neuroimaging study of motoric cognitive risk syndrome in patients with cerebral small vessel disease
10.19845/j.cnki.zfysjjbzz.2026.0007
- VernacularTitle:脑小血管病患者运动认知风险综合征的神经影像学研究
- Author:
Xiaokai HU
1
;
Yujuan DONG
1
Author Information
1. Department of Neurology， Hebei Medical University Third Hospital， Shijiazhuang 050051， China
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Motoric cognitive risk syndrome;
Mild cognitive impairment;
Gait disturbance;
Imaging markers
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(1):40-46
- CountryChina
- Language:Chinese
-
Abstract:
摘要
目的 探讨脑小血管病（CSVD）患者中运动认知风险综合征（MCR）与神经影像学标志物之间的关系，并评估MCR相关的影像学标志物及比较其与轻度认知功能障碍（MCI）的影像学标志物是否不同。方法 研究回顾性选取了河北医科大学第三医院自2023年4月—2024年11月收治的187例脑小血管病患者。根据是否诊断MCR及MCI进行分组。收集患者的临床资料和影像学数据，使用单变量和多因素Logistic回归分析探讨CSVD患者MCR的影像学特征。结果 CSVD患者中MCR阳性组在体重指数（BMI）、男性比例、高血压、存在腔隙、严重的脑白质高信号（WMH）、严重的基底节区扩大的血管周围间隙（EPVS）和严重CSVD总负荷方面患者比例比MCR阴性组更高（P<0.05）。多因素Logistic回归分析显示，WMH总体积是CSVD患者MCR的独立危险因素（OR=1.038，95%CI 1.003~1.075，P=0.033）。以MCI、MCR两个指标分组显示，MCI+/MCR+较其他组比较，高血压病比例更高（其中MCI-/MCR+组较MCI+/MCR-组比高血压病比例更高），WMH总体积、严重的脑深部及脑室旁WMH、严重的EPVS比例更高（P<0.05）。其中单纯MCR阳性组（MCI-/MCR+）与单纯MCI阳性组（MCI+/MCR-）比较，脑室旁及深部WMH有更高的分级（2级、3级高于MCI+/MCR-组）及更大的总体积（P<0.05）。CSVD总负荷方面差异无统计学意义（P>0.05）。结论 WMH是CSVD患者合并MCR的独立危险因素。MCR与更大的WMH体积相关。本研究强调了MCR的脑白质异常，运动评估在早期痴呆风险分层中的潜力。
Abstract
Objective To investigate the association between motoric cognitive risk syndrome （MCR） and neuroimaging markers in patients with cerebral small vessel disease （CSVD）， to assess the imaging markers associated with MCR， and to compare the differences in imaging markers between MCR and mild cognitive impairment （MCI）. Methods A retrospective study was conducted among 187 patients with CSVD who were admitted to Department of Neurology， Hebei Medical University Third Hospital， from April 2023 to November 2024， and they were divided into groups based on whether they were diagnosed with MCR or MCI. Clinical and imaging data were collected， and the univariate and multivariate logistic regression analyses were used to investigate the imaging features of CSVD patients with MCR. Results Compared with the MCR-negative group， the MCR-positive group had significantly higher BMI， proportion of male patients，and proportion of patients with hypertension， lacunar infarcts， severe white matter hyperintensity （WMH）， severe enlarged perivascular space （EPVS） in the basal ganglia， and high CSVD total burden （P<0.05）. The multivariate logistic regression analysis showed that the total volume of WMH was an independent risk factor for MCR in CSVD patients（OR=1.038，95%CI 1.003‒1.075，P=0.033）. Stratification by MCI，MCR showed that compared with the other groups， the MCI+/MCR+ group had a significantly higher proportion of patients with hypertension （the MCI-/MCR+ group had a higher proportion of patients with hypertension than the MCI+/MCR- group）， a significantly higher total volume of WMH， a significantly higher proportion of patients with severe deep brain and paraventricular WMH， and a significantly higher proportion of patients with severe EPVS（P<0.05）.Compared with the MCI+/MCR-group， the MCI-/MCR+ group had significantly higher grades （a significantly higher proportion of patients with grade 2 or 3 WMH than the MCI+/MCR- group） and total volume of periventricular and deep WMH（P<0.05）. There was no significant difference in CSVD total burden between groups（P>0.05）. Conclusion WMH is an independent risk factor for MCR in patients with CSVD. MCR is associated with a larger volume of WMH.This study highlights white matter abnormalities in MCR and the potential of motor function assessment in early risk stratification for dementia.
- Full text:2026020509525566230脑小血管病患者运动认知风险综合征的神经影像学研究.pdf
