Metabolic adaptation and therapeutic resistance in breast cancer: challenges and future directions
10.19405/j.cnki.issn1000-1492.2025.05.001
- Author:
Zhengsheng Wu
1
Author Information
1. Dept of Pathology , School of Basic Medical Sciences , Anhui Medical University , Hefei 230032; Dept of Pathology , The First Afiliated Hospital of Anhui Medical University , Hefei 230022
- Publication Type:Review
- Keywords:
breast cancer;
invasion and metastasis;
metabolic reprogramming;
therapeutic resistance;
metabolic targets;
precision therapy
- From:
Acta Universitatis Medicinalis Anhui
2025;60(5):773-777
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Breast cancer is the most common malignancy among women worldwide, and its recurrence, metastasis, and drug resistance remain significant challenges in systemic treatment. Metabolic alterations are a hallmark of cancer, with breast cancer cells reprogramming glucose metabolism, lipid metabolism, and amino acid metabolism to adapt their nutrient acquisition pathways. This metabolic reprogramming enables cancer cells to meet the energy demands for rapid proliferation and adaption to the microenvironment of metastatic sites, which is closely associated with resistance to chemotherapy, targeted therapies, and immunotherapies. This review summarizes the features of metabolic remodeling in breast cancer, the mechanisms by which metabolic adaptation contributes to treatment resistance, and emerging individualized strategies targeting metabolic vulnerabilities. Particular focus is placed on energy metabolism, cholesterol homeostasis, and glutamine utilization in relation to tumor invasion, metastasis, and drug resistance. A better understanding of metabolic adaptation and accurate monitoring of metabolic dynamics may offer new insights into metabolic therapies and improve clinical outcomes.
- Full text:2026020509483676452乳腺癌的代谢适应与治疗抵抗：挑战与前景_吴正升.pdf
