Application value of occupational therapy in cognitive impairment in patients with cerebral small vessel disease
10.19845/j.cnki.zfysjjbzz.2026.0006
- VernacularTitle:作业疗法在脑小血管病患者认知功能损伤中的应用价值
- Author:
Man WANG
1
Author Information
1. Department of Rehabilitation Medicine， The First People Hospital of Shangqiu， Shangqiu 476000， China
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Cognitive impairment;
Occupational therapy;
Cerebral blood perfusion;
High-sensitivity C reactive protein;
Homocysteine
- MeSH:
Homocysteine
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(1):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of occupational therapy in cognitive impairment in patients with cerebral small vessel disease. Methods A total of 84 patients with cerebral small vessel disease who were admitted to our hospital from April 2021 to September 2022 and were found to have cognitive impairment were enrolled as subjects， and they were randomly divided into observation group and control group using a random number table， with 42 patients in each group. The patients in the control group received conventional Western medicine treatment， while those in the observation group received occupational therapy in addition to the treatment in the control group. After 8 weeks of continuous treatment， the two groups were compared in terms of treatment outcome， Mini-Mental State Examination （MMSE） score， Montreal Cognitive Assessment （MoCA） score， brain-derived neurotrophic factor （BDNF）， high-sensitivity C reactive protein （hs-CRP）， homocysteine （Hcy）， and cerebral blood perfusion parameters. Results The treatment group had a higher overall response rate than the control group （95.24% vs 73.81%， P<0.05）. After treatment， the observation group had significantly higher MMSE， MoCA， and MBI scores than the control group （P<0.05）. Compared with the control group， the observation group had a significantly lower MTT and significantly higher CBV and CBF （P<0.05）. Compared with the control group， the observation group had a significantly higher level of BDNF and significantly lower levels of hs-CRP and Hcy （P<0.05）. Conclusion Occupational therapy has a marked clinical effect in patients with cerebral small vessel disease and cognitive impairment and can effectively improve cognitive function and cerebral blood perfusion， upregulate the level of BDNF， and reduce the expression of hs-CRP and Hcy. It is of great significance for improving the quality of life and prognosis of patients.
- Full text:2026020509450482228作业疗法在脑小血管病患者认知功能损伤中的应用价值.pdf
