Research progress of mitophagy in asthma
- Author:
Yingzhi He
1
;
You Wang
1
;
Xuemei Chen
1
;
Yuwei Xie
1
;
Dang Ao
1
;
Chuanghong Ke
1
;
Wen Li
1
Author Information
- Publication Type:Review
- Keywords: asthma; airway remodeling; mitophagy; Parkin-dependent mitophagy; Parkin-independent mitoph- agy; mitophagy inhibitor; mitophagy agonist
- From: Acta Universitatis Medicinalis Anhui 2025;60(4):766-771
- CountryChina
- Language:Chinese
- Abstract: Abstract:Asthma is a well-characterized heterogeneous disease marked by airway remodeling and chronic airway inflammation. Clinically, the treatment of asthma primarily relies on hormonal drugs. However, the long-term use of these medications can lead to significant side effects. Mitophagy is a biological process that selectively transports damaged mitochondria to lysosomes for degradation. Recent research has revealed the crosstalk between mitophagy and asthma. Accordingly, taking mitophagy as an entry point, summarizing the key molecular mechanisms and regulators of mitophagy in asthma will facilitate the development of novel intervention targets and strategies for asthmatic treatment.
- Full text:202602041721293253线粒体自噬调控哮喘的研究进展_何鎣芝.pdf
