Research progress on the regulation of JNK signaling pathway by traditional Chinese medicine for intervention in central nervous system diseases
- VernacularTitle:中药调控JNK信号通路干预中枢神经系统疾病的研究进展
- Author:
Hongwei WANG
1
;
Mingliang QIAO
2
;
Chenyi ZHAO
2
;
Pei ZHU
1
;
Zilong WEI
1
;
Yi MENG
2
Author Information
1. Second School of Clinical Medicine，Henan University of Chinese Medicine，Zhengzhou 450002，China
2. Dept. of Geriatrics，Henan Provincial Hospital of Traditional Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
central nervous system diseases;
JNK signaling pathway;
TCM monomers;
TCM compound formulation
- From:
China Pharmacy
2026;37(2):257-262
- CountryChina
- Language:Chinese
-
Abstract:
The c-Jun N-terminal kinase （JNK） signaling pathway， a key member of the mitogen-activated protein kinase （MAPK） family， plays a central role in the pathogenesis and progression of central nervous system （CNS） diseases by regulating core biological processes such as apoptosis， inflammatory responses， synaptic plasticity， and autophagy. This article sorts out and analyzes relevant literature published domestically and internationally in recent years， summarizing the mechanisms of action of the JNK signaling pathway in common CNS diseases and the research progress in traditional Chinese medicine （TCM） interventions in CNS diseases through the regulation of the JNK signaling pathway. Studies have shown that active components of TCM， such as berberine， paeoniflorin， and astragaloside Ⅳ， as well as compound formulations like Heixiaoyao san， Ditan tang， and Buyang huanwu tang， can exert neuroprotective effects in various CNS disorders， including Alzheimer’s disease， Parkinson’s disease， cerebral ischemia-reperfusion injury， and epilepsy， by inhibiting the aberrant activation of the JNK signaling pathway， thereby alleviating neuroinflammation， oxidative stress， and neuronal apoptosis， while improving synaptic function and cognitive behavioral deficits， regulating autophagy， and maintaining blood-brain barrier integrity.
