Evaluation of transdermal absorption of self-assembled nanoparticles of Huangqin decoction loaded with terbinafine
- VernacularTitle:负载特比萘芬的黄芩汤自组装纳米粒的透皮吸收评价
- Author:
Chengying SHEN
1
;
Yican HE
2
;
Xiao CHENG
3
;
Chaoying DU
1
;
Hongyan MIN
4
;
Baode SHEN
3
;
Lingfei TONG
1
Author Information
1. Dept. of Pharmacy，Jiangxi Provincial People’s Hospital （the First Affiliated Hospital of Nanchang Medical College），Nanchang 330006，China
2. School of Pharmacy，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
3. Key Laboratory of Modern Preparation of Traditional Chinese Medicine，Ministry of Education，Jiangxi University of Chinese Medicine，Nanchang 330004，China
4. School of Pharmacy，Nanchang Medical College，Nanchang 330052，China
- Publication Type:Journal Article
- Keywords:
terbinafine;
Huangqin decoction;
self-assembled nanoparticles;
transdermal absorption;
skin retention
- From:
China Pharmacy
2026;37(2):180-185
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of Huangqin decoction （HQD）-based self-assembled nanoparticles （SAN） co-loaded with terbinafine （TBF） （TBF-HQD-SAN NPs） on the transdermal absorption of TBF. METHODS High-speed centrifugation combined with dialysis was used to separate HQD-SAN， and TBF-HQD-SAN NPs were obtained by loading TBF using the ultrasound magnetic stirring method； the particle size distribution， Zeta potential and polydispersity index （PDI） of the nanoparticle were characterized， and the encapsulation efficiency （EE） and drug loading （DL） of TBF were determined； using in vitro and in vivo transdermal experiments， the differences in transdermal performance between TBF-HQD-SAN NPs and TBF raw materials， as well as TBF and HQD-SAN physical mixture （TBF-HQD-SAN PM）， were compared and analyzed. RESULTS TBF- HQD-SAN NPs were spherical with a particle size of （177.60±2.57） nm， a PDI of 0.197 4±0.007 9， and a Zeta potential of （－14.63±0.85） mV. The EE and DL of TBF were （99.49±0.71）% and （3.22±0.10）% ， respectively. In vitro transdermal experiments， compared with TBF raw materials， the steady-state permeation rate （Jss） and skin retention of TBF-HQD-SAN NPs increased by 3.34 times and 27.56 times， respectively （P＜0.05）； compared with TBF-HQD-SAN PM， its Jss and skinretention were increased by 2.04 times and 7.44 times， respectively （P＜0.05）. In vivo transdermal experiments 69号） showed that， the area under the drug-time curve and the maximum concentration of TBF-HQD-SAN NPs increased by 2.13 times and 2.06 times respectively compared to TBF raw materials， and increased by 1.59 times and 1.65 times respectively compared to TBF-HQD-SAN PM （P＜0.05）. CONCLUSIONS TBF-HQD-SAN NPs can significantly enhance the in vitro and in vivo transdermal absorption efficiency and skin retention of TBF.
