Correlations of computed tomography angiography-derived coronary plaque properties with platelet function and whole blood cell-derived inflammatory markers in elderly patients with coronary heart disease
10.13491/j.issn.1004-714X.2025.06.018
- VernacularTitle:CTA冠脉斑块性质与老年冠心病患者血小板功能及全血细胞衍生的炎症标志物的相关性
- Author:
Xiaona LI
1
;
Yan LU
2
;
Fei DONG
3
;
Zhuoxuan YANG
1
;
Chen LIANG
4
Author Information
1. Department of Cardiovascular Medicine, Yuncheng Central Hospital Affiliated to Shanxi Medical University, Yuncheng 044000, China.
2. Department of Cardiovascular Medicine, First Hospital of Shanxi Medical University, Taiyuan 030000, China.
3. Department of Medical Imaging, Yuncheng Central Hospital Affiliated to Shanxi Medical University, Yuncheng 044000, China.
4. Yuncheng Vocational Nursing College, Yuncheng 044000, China.
- Publication Type:OriginalArticles
- Keywords:
Computed tomography angiography;
Coronary plaque;
Coronary heart disease;
Platelet;
Inflammatory marker
- From:
Chinese Journal of Radiological Health
2025;34(6):896-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships of computed tomography (CT) angiography (CTA)-derived coronary plaque properties with platelet function and whole blood cell-derived inflammatory markers in elderly patients with coronary heart disease. Methods The clinical data of 142 elderly patients with coronary heart disease who underwent coronary CTA examination in the hospital between April 2022 and April 2025 were retrospectively analyzed. The CT value of CTA, platelet function parameters (mean platelet volume, platelet-derived growth factor BB, von Willebrand factor), and whole blood cell-derived inflammatory markers were recorded at admission. The correlations of the CT value of CTA-derived coronary plaque properties with platelet function parameters and whole blood cell-derived inflammatory markers in elderly patients with coronary heart disease were analyzed using Pearson correlation coefficients. Based on the evaluation of CTA-derived coronary plaque properties, the patients were divided into a soft plaque group (CT value ≤ 60 HU), a calcified plaque group (CT value ≥ 130 HU), and a mixed plaque group (60 HU < CT value < 130 HU). The platelet function parameters (mean platelet volume, platelet-derived growth factor BB, von Willebrand factor) and whole blood cell-derived inflammatory markers (systemic immune-inflammation index, systemic inflammation response index, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio) on admission were compared among the three groups. Results The coronary CTA examination showed 37 (26.06%) cases in the calcified plaque group, 47 (33.10%) cases in the soft plaque group, and 58 (40.84%) cases in the mixed plaque group. The CT values were (189.57 ± 22.14) HU for the calcified plaque group, (31.74 ± 4.12) HU for the soft plaque group, and (94.52 ± 8.29) HU for the mixed plaque group. The levels of platelet function parameters and whole blood cell-derived inflammatory markers at admission were in the following order: soft plaque group > mixed plaque group > calcified plaque group, and the differences were statistically significant (P < 0.05). After adjustment for sex, age, cardiac function grading, hypertension, diabetes, and blood lipids as covariates, partial correlation analysis revealed that the CT value of CTA-derived coronary plaque properties in elderly patients with coronary heart disease was negatively correlated with the levels of platelet function parameters and whole blood cell-derived inflammatory markers (P < 0.05). Conclusion In this study, the coronary plaque CT value in elderly patients with coronary heart disease was negatively correlated with the levels of platelet function parameters and whole blood cell-derived inflammatory markers. Furthermore, increasing plaque instability may be associated with more pronounced platelet activation and a heightened systemic inflammatory state.
