Exploration of Traditional Chinese Medicine Syndrome Characteristics in A Heart Failure Model Induced by Coronary Artery Ligation Based on Method of Syndrome Identification by Prescription Efficacy
10.13422/j.cnki.syfjx.20250918
- VernacularTitle:基于“以方测证”探讨冠状动脉结扎诱导的心力衰竭模型中医证候属性
- Author:
Xiaoqian LIAO
1
;
Peiyao LI
1
;
Xingyu FAN
2
;
Zhenyu ZHAO
1
;
Junyu ZHANG
1
;
Yuehang XU
1
;
Zhixi HU
1
Author Information
1. School of Traditional Chinese Medicine（TCM）， Hunan University of Chinese Medicine， Changsha 410208， China
2. College of TCM， Hubei University of Chinese Medicine， Wuhan 430065， China
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
syndrome identification by prescription efficacy;
coronary artery ligation;
traditional Chinese medicine injection
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(5):169-177
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure （CHF） is a major global public health problem， and myocardial infarction is one of its main causes. The mouse model of heart failure induced by coronary artery ligation is widely used in the study of CHF， while the TCM syndrome attributes of this model have not yet been clarified. According to the theory of correspondence between prescriptions and syndromes， the method of syndrome identification by prescription efficacy is an important means of current syndrome research of animal models. This method deduces the syndrome characteristics of animal models through prescription efficacy. Taking the four basic syndrome elements of Qi， blood， Yin and Yang as the classification reference， this study used coronary artery ligation to construct a mouse model of CHF and treated the model with four representative TCM injections with the effects of replenishing Qi， warming Yang， nourishing Yin， and activating blood and enalapril. Echocardiography， tongue color parameters， histopathology， serum N-terminal pro-brain natriuretic peptide （NT-proBNP） and cardiac troponin Ⅰ （cTnⅠ） levels， and systematically explored the TCM syndrome attributes of this model. The results showed that the coronary ligation model presented an obvious cardiac function decline， myocardial fibrosis， infarct size expansion， and purple dark tongue， which were consistent with the basic syndrome characteristics of blood stasis in CHF. Danhong injection had significant effects of improving the cardiac function， alleviating myocardial fibrosis， and reducing serum NT-proBNP and cTnⅠ levels. Huangqi Injection and Shenfu injection can improve the cardiac function and tongue color parameters， with limited effects. The effect of Shenmai injection group was not obvious. This study verifies that the established model conforms to blood stasis syndrome through the method of syndrome identification by prescription efficacy， which provides an experimental basis for the study of TCM syndrome mechanism of CHF.
