Traditional Chinese Medicine Treatment of Chronic Heart Failure Based on AMPK Signaling Pathway
10.13422/j.cnki.syfjx.20250915
- VernacularTitle:基于AMPK信号通路探讨慢性心力衰竭的中医药治疗
- Author:
Kun LIAN
1
;
Lichong MENG
1
;
Xueqin WANG
1
;
Yubin ZHANG
1
;
Lin LI
1
;
Xuhui TANG
1
;
Zhixi HU
1
Author Information
1. Hunan University of Chinese Medicine， Changsha 410208， China
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
adenosine monophosphate-activated protein kinase;
traditional Chinese medicine treatment;
energy metabolism;
autophagy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(5):139-148
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure （CHF） is a group of complex clinical syndromes caused by abnormal changes in the structure and/or function of the heart due to various reasons， resulting in disorders of ventricular contraction and/or diastole. CHF is a condition where primary diseases such as coronary heart disease， hypertension and pulmonary heart disease recur frequently and persist for a long time， presenting blood stasis in meridians and collaterals， stagnation of water and dampness， and accumulation of Qi in collaterals. Its pathogenesis is complex and may involve myocardial energy metabolism disorders， oxidative stress responses， myocardial cell apoptosis， autophagy， inflammatory responses， etc. According to the theory of restraining hyperactivity to acquire harmony， we believe that under normal circumstances， the adenosine monophosphate-activated protein kinase （AMPK） signaling pathway functions normally， maintaining human physiological activities and energy metabolism. Under pathological conditions， the AMPK signaling pathway is abnormal， causing energy metabolism disorders， inflammatory responses， and myocardial fibrosis. Traditional Chinese medicine （TCM） can regulate the AMPK signaling pathway through multiple mechanisms， targets， and effects， effectively curbing the occurrence and development of CHF. It has gradually become a research hotspot in the prevention and treatment of this disease. Guided by the theory of TCM， our research group， through literature review， summarized the relationship between the AMPK pathway and CHF and reviewed the research progress in the prevention and control of CHF with TCM active ingredients， TCM compound prescriptions， and Chinese patent medicines via regulating the AMPK pathway. The review aims to clarify the mechanism and targets of TCM in the treatment of CHF by regulating the AMPK pathway and guide the clinical treatment and drug development for CHF.
